Dual Receptor-Targeted Theranostic Nanoparticles for Localized Delivery and Activation of Photodynamic Therapy Drug in Glioblastomas

Targeting gold nanoparticles (AuNPs) with two or more receptor binding peptides has been proposed to address intratumoral heterogeneity of glioblastomas that overexpress multiple cell surface receptors to ultimately improve therapeutic efficacy. AuNPs conjugated with peptides against both the epider...

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Udgivet i:Mol Pharm
Main Authors: Dixit, Suraj, Miller, Kayla, Zhu, Yun, McKinnon, Emilie, Novak, Thomas, Kenney, Malcolm E., Broome, Ann-Marie
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564323/
https://ncbi.nlm.nih.gov/pubmed/26198693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00216
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id pubmed-4564323
record_format dspace
spelling pubmed-45643232016-09-08 Dual Receptor-Targeted Theranostic Nanoparticles for Localized Delivery and Activation of Photodynamic Therapy Drug in Glioblastomas Dixit, Suraj Miller, Kayla Zhu, Yun McKinnon, Emilie Novak, Thomas Kenney, Malcolm E. Broome, Ann-Marie Mol Pharm Article Targeting gold nanoparticles (AuNPs) with two or more receptor binding peptides has been proposed to address intratumoral heterogeneity of glioblastomas that overexpress multiple cell surface receptors to ultimately improve therapeutic efficacy. AuNPs conjugated with peptides against both the epidermal growth factor and transferrin receptors and loaded with the photosensitizer phthalocyanine 4 (Pc 4) have been designed and compared with monotargeted AuNPs for in vitro and in vivo studies. The (EGF(pep)+Tf(pep))-AuNPs-Pc 4 with a particle size of ~41 nm improved both specificity and worked synergistically to decrease time of maximal accumulation in human glioma cells that overexpressed two cell surface receptors as compared to cells that overexpressed only one. Enhanced cellular association and increased cytotoxicity were achieved. In vivo studies show notable accumulation of these agents in the brain tumor regions. [Image: see text] 2015-08-24 2015-09-08 /pmc/articles/PMC4564323/ /pubmed/26198693 http://dx.doi.org/10.1021/acs.molpharmaceut.5b00216 Text en
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Article
spellingShingle Article
Dixit, Suraj
Miller, Kayla
Zhu, Yun
McKinnon, Emilie
Novak, Thomas
Kenney, Malcolm E.
Broome, Ann-Marie
Dual Receptor-Targeted Theranostic Nanoparticles for Localized Delivery and Activation of Photodynamic Therapy Drug in Glioblastomas
description Targeting gold nanoparticles (AuNPs) with two or more receptor binding peptides has been proposed to address intratumoral heterogeneity of glioblastomas that overexpress multiple cell surface receptors to ultimately improve therapeutic efficacy. AuNPs conjugated with peptides against both the epidermal growth factor and transferrin receptors and loaded with the photosensitizer phthalocyanine 4 (Pc 4) have been designed and compared with monotargeted AuNPs for in vitro and in vivo studies. The (EGF(pep)+Tf(pep))-AuNPs-Pc 4 with a particle size of ~41 nm improved both specificity and worked synergistically to decrease time of maximal accumulation in human glioma cells that overexpressed two cell surface receptors as compared to cells that overexpressed only one. Enhanced cellular association and increased cytotoxicity were achieved. In vivo studies show notable accumulation of these agents in the brain tumor regions. [Image: see text]
author Dixit, Suraj
Miller, Kayla
Zhu, Yun
McKinnon, Emilie
Novak, Thomas
Kenney, Malcolm E.
Broome, Ann-Marie
author_facet Dixit, Suraj
Miller, Kayla
Zhu, Yun
McKinnon, Emilie
Novak, Thomas
Kenney, Malcolm E.
Broome, Ann-Marie
author_sort Dixit, Suraj
title Dual Receptor-Targeted Theranostic Nanoparticles for Localized Delivery and Activation of Photodynamic Therapy Drug in Glioblastomas
title_short Dual Receptor-Targeted Theranostic Nanoparticles for Localized Delivery and Activation of Photodynamic Therapy Drug in Glioblastomas
title_full Dual Receptor-Targeted Theranostic Nanoparticles for Localized Delivery and Activation of Photodynamic Therapy Drug in Glioblastomas
title_fullStr Dual Receptor-Targeted Theranostic Nanoparticles for Localized Delivery and Activation of Photodynamic Therapy Drug in Glioblastomas
title_full_unstemmed Dual Receptor-Targeted Theranostic Nanoparticles for Localized Delivery and Activation of Photodynamic Therapy Drug in Glioblastomas
title_sort dual receptor-targeted theranostic nanoparticles for localized delivery and activation of photodynamic therapy drug in glioblastomas
container_title Mol Pharm
publishDate 2015
url https://ncbi.nlm.nih.gov/pmc/articles/PMC4564323/
https://ncbi.nlm.nih.gov/pubmed/26198693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00216
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