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Atrial SERCA2a Overexpression Has No Affect on Cardiac Alternans but Promotes Arrhythmogenic SR Ca(2+) Triggers

BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia in humans, yet; treatment has remained sub-optimal due to poor understanding of the underlying mechanisms. Cardiac alternans precede AF episodes, suggesting an important arrhythmia substrate. Recently, we demonstrated ventricular SER...

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Publicat a:PLoS One
Autors principals: Nassal, Michelle M. J., Wan, Xiaoping, Laurita, Kenneth R., Cutler, Michael J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564245/
https://ncbi.nlm.nih.gov/pubmed/26352986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137359
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