Single-Cell Analysis and Next-Generation Immuno-Sequencing Show That Multiple Clones Persist in Patients with Chronic Lymphocytic Leukemia

The immunoglobulin heavy chain (IGH) gene rearrangement in chronic lymphocytic leukemia (CLL) provides a unique molecular signature; however, we demonstrate that 26/198 CLL patients (13%) had more than one IGH rearrangement, indicating the power of molecular technology over phenotypic analysis. Sing...

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Udgivet i:PLoS One
Main Authors: Kriangkum, Jitra, Motz, Sarah N., Mack, Tanner, Beiggi, Sara, Baigorri, Eva, Kuppusamy, Hemalatha, Belch, Andrew R., Johnston, James B., Pilarski, Linda M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564241/
https://ncbi.nlm.nih.gov/pubmed/26353109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137232
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