Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity

The small-molecule inhibitor of p53-Mdm2 interaction, Nutlin-3, is known to be effective against cancers expressing wild-type (wt) p53. p53 mutations are rare in nasopharyngeal carcinoma (NPC), hence targeting disruption of p53-Mdm2 interaction to reactivate p53 may offer a promising therapeutic str...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncol Rep
Auteurs principaux: VOON, YEE-LIN, AHMAD, MUNIRAH, WONG, POOI-FONG, HUSAINI, ROSLINA, NG, WAYNE TIONG-WENG, LEONG, CHEE-ONN, LANE, DAVID PHILIP, KHOO, ALAN SOO-BENG
Format: Artigo
Langue:Inglês
Publié: D.A. Spandidos 2015
Sujets:
Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564086/
https://ncbi.nlm.nih.gov/pubmed/26252575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2015.4177
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