Increased H3K9me3 drives dedifferentiated phenotype via KLF6 repression in liposarcoma

Liposarcoma (LPS) can be divided into 4 different subtypes, of which well-differentiated LPS (WDLPS) and dedifferentiated LPS (DDLPS) are the most common. WDLPS is typically low grade, whereas DDLPS is high grade, aggressive, and carries a worse prognosis. WDLPS and DDLPS frequently co-occur in pati...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Keung, Emily Z., Akdemir, Kadir C., Al Sannaa, Ghadah A., Garnett, Jeannine, Lev, Dina, Torres, Keila E., Lazar, Alexander J., Rai, Kunal, Chin, Lynda
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563740/
https://ncbi.nlm.nih.gov/pubmed/26193637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77976
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