Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage

Patients with inflammatory bowel disease are at increased risk for colon cancer due to augmented oxidative stress. These patients also have compromised antioxidant defenses as the result of nutritional deficiencies. The micronutrient selenium is essential for selenoprotein production and is transpor...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Barrett, Caitlyn W., Reddy, Vishruth K., Short, Sarah P., Motley, Amy K., Lintel, Mary K., Bradley, Amber M., Freeman, Tanner, Vallance, Jefferson, Ning, Wei, Parang, Bobak, Poindexter, Shenika V., Fingleton, Barbara, Chen, Xi, Washington, Mary K., Wilson, Keith T., Shroyer, Noah F., Hill, Kristina E., Burk, Raymond F., Williams, Christopher S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563672/
https://ncbi.nlm.nih.gov/pubmed/26053663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76099
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