Comparison of digital PCR platforms and semi-nested qPCR as a tool to determine the size of the HIV reservoir

HIV persists in latently infected cells of patients on antiretroviral therapy (ART). This persistent proviral DNA reservoir is an important predictor of viral rebound upon therapy failure or interruption and forms a major obstacle towards cure. Accurate quantification of the low levels of persisting...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Bosman, K. J., Nijhuis, M., van Ham, P. M., Wensing, A. M. J., Vervisch, K., Vandekerckhove, L., De Spiegelaere, W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563360/
https://ncbi.nlm.nih.gov/pubmed/26350506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13811
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