Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

OBJECTIVE: Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides and nucleosides are important regulators of adipocyte function, but the pathway for controlled ATP release from adipoc...

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Veröffentlicht in:Mol Metab
Hauptverfasser: Adamson, Samantha E., Meher, Akshaya K., Chiu, Yu-hsin, Sandilos, Joanna K., Oberholtzer, Nathaniel P., Walker, Natalie N., Hargett, Stefan R., Seaman, Scott A., Peirce-Cottler, Shayn M., Isakson, Brant E., McNamara, Coleen A., Keller, Susanna R., Harris, Thurl E., Bayliss, Douglas A., Leitinger, Norbert
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563021/
https://ncbi.nlm.nih.gov/pubmed/26413467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2015.06.009
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