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Syntheses and Studies of New Forms of N-Sulfonyloxy β-Lactams as Potential Antibacterial Agents and β-Lactamase Inhibitors

The synthesis of a small library of N-sulfonyloxy-2-azetidinones is reported and the preliminary results of the investigation of the biological activity of these molecules are discussed. These new multi-electrophilic β-lactams (“electrophilic bombs”) display unexpected selectivity in their antibacte...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Carosso, Serena, Miller, Marvin J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562877/
https://ncbi.nlm.nih.gov/pubmed/26321604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.08.005
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