Cytokine-dependent bidirectional connection between impaired social behavior and susceptibility to seizures associated with maternal immune activation in mice

Maternal immune activation (MIA) results in the development of autism in the offspring via hyperactivation of IL-6 signaling. Furthermore, experimental studies showed that the MIA-associated activation of interleukin-1β (IL-1β) concurrently with IL-6 increases the rate and the severity of hippocampa...

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Veröffentlicht in:Epilepsy Behav
Hauptverfasser: Washington, James, Kumar, Udaya, Medel-Matus, Jesus-Servando, Shin, Don, Sankar, Raman, Mazarati, Andrey
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562803/
https://ncbi.nlm.nih.gov/pubmed/26103532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yebeh.2015.05.040
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