Individual T Helper Cells Have a Quantitative Cytokine Memory

The probabilistic expression of cytokine genes in differentiated T helper (Th) cell populations remains ill defined. By single-cell analyses and mathematical modeling, we show that one stimulation featured stable cytokine nonproducers as well as stable producers with wide cell-to-cell variability in...

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Veröffentlicht in:Immunity
Hauptverfasser: Helmstetter, Caroline, Flossdorf, Michael, Peine, Michael, Kupz, Andreas, Zhu, Jinfang, Hegazy, Ahmed N., Duque-Correa, Maria A., Zhang, Qin, Vainshtein, Yevhen, Radbruch, Andreas, Kaufmann, Stefan H., Paul, William E., Höfer, Thomas, Löhning, Max
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562415/
https://ncbi.nlm.nih.gov/pubmed/25607461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.12.018
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