STAT1 modification improves therapeutic effects of interferons on lung cancer cells

BACKGROUND: Interferons (IFNs) have potent anti-proliferative, pro-apoptotic, and immunomodulatory activities against cancer. However, the clinical utility of IFNs is limited by toxicity and pharmacokinetics making it difficult to achieve sustained therapeutic levels especially in solid tumors. METH...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Chen, Junjie, Zhao, Jialu, Chen, Lefu, Dong, Nian, Ying, Zhaojian, Cai, Zhenzhen, Ji, Dongxiang, Zhang, Yong, Dong, Li, Li, Yuping, Jiang, Lei, Holtzman, Michael J., Chen, Chengshui
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562290/
https://ncbi.nlm.nih.gov/pubmed/26351076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0656-0
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