A Mixture Dose–Response Model for Identifying High-Dimensional Drug Interaction Effects on Myopathy Using Electronic Medical Record Databases

Interactions between multiple drugs may yield excessive risk of adverse effects. This increased risk is not uniform for all combinations, although some combinations may have constant adverse effect risks. We developed a statistical model using medical record data to identify drug combinations that i...

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Detalles Bibliográficos
Publicado en:CPT Pharmacometrics Syst Pharmacol
Autores principales: Zhang, P, Du, L, Wang, L, Liu, M, Cheng, L, Chiang, C-W, Wu, H-Y, Quinney, SK, Shen, L, Li, L
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley & Sons, Ltd 2015
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562163/
https://ncbi.nlm.nih.gov/pubmed/26380156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.53
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