Combined Antiviral Therapy Using Designed Molecular Scaffolds Targeting Two Distinct Viral Functions, HIV-1 Genome Integration and Capsid Assembly

Designed molecular scaffolds have been proposed as alternative therapeutic agents against HIV-1. The ankyrin repeat protein (Ank(GAG)1D4) and the zinc finger protein (2LTRZFP) have recently been characterized as intracellular antivirals, but these molecules, used individually, do not completely bloc...

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Publicat a:Mol Ther Nucleic Acids
Autors principals: Khamaikawin, Wannisa, Saoin, Somphot, Nangola, Sawitree, Chupradit, Koollawat, Sakkhachornphop, Supachai, Hadpech, Sudarat, Onlamoon, Nattawat, Ansari, Aftab A, Byrareddy, Siddappa N, Boulanger, Pierre, Hong, Saw-See, Torbett, Bruce E, Tayapiwatana, Chatchai
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560793/
https://ncbi.nlm.nih.gov/pubmed/26305555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.22
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