A phase II trial of the nucleolin-targeted DNA aptamer AS1411 in metastatic refractory renal cell carcinoma

BACKGROUND: DNA aptamers represent a novel strategy in anti-cancer medicine. These compounds are short sequences of DNA that have protein binding effects via shape specific recognition of a target protein in an interaction which is analogous to antibody-antigen binding. AS1411, a DNA aptamer that ta...

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Udgivet i:Invest New Drugs
Main Authors: Rosenberg, Jonathan E., Bambury, Richard, Drabkin, Harry A., Lara, Primo N., Harzstark, Andrea L., Figlin, Robert A., Smith, Gregory W., Choueiri, Toni, Erlandsson, Fredrik, Laber, Damian A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560460/
https://ncbi.nlm.nih.gov/pubmed/24242861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-013-0045-6
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