Human Herpesvirus-6 U14 Induces Cell-Cycle Arrest in G2/M Phase by Associating with a Cellular Protein, EDD

The human herpesvirus-6 (HHV-6) infection induces cell-cycle arrest. In this study, we found that the HHV-6-encoded U14 protein induced cell-cycle arrest at G2/M phase via an association with the cellular protein EDD, a mediator of DNA-damage signal transduction. In the early phase of HHV-6 infectio...

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Udgivet i:PLoS One
Main Authors: Mori, Junko, Kawabata, Akiko, Tang, Huamin, Tadagaki, Kenjiro, Mizuguchi, Hiroyuki, Kuroda, Kazumichi, Mori, Yasuko
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560387/
https://ncbi.nlm.nih.gov/pubmed/26340541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137420
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