Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons

Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to regulate the transcription of CREB target gen...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Ch'ng, Toh Hean, DeSalvo, Martina, Lin, Peter, Vashisht, Ajay, Wohlschlegel, James A., Martin, Kelsey C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560099/
https://ncbi.nlm.nih.gov/pubmed/26388727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2015.00048
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