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Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease
The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an abundant structural, sensory, and signaling filament in muscle) as a common cause of end-stage dilated cardiomyopathy (DCM) provides new prospects for improving heart failure management. However, realizatio...
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| Veröffentlicht in: | Sci Transl Med |
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4560092/ https://ncbi.nlm.nih.gov/pubmed/25589632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010134 |
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