Suppression of in vitro megakaryopoiesis by maternal sera containing anti-HPA-1a antibodies

Incompatibility of the human platelet antigen-1 (HPA-1) system is the most common cause of fetal/neonatal alloimmune thrombocytopenia (F/NAIT) and is thought to be mediated by accelerated clearance of antibody-opsonized fetal platelets. We evaluated the effect of maternal sera containing anti-HPA-1a...

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Bibliographic Details
Published in:Blood
Main Authors: Liu, Zhi-Jian, Bussel, James B., Lakkaraja, Madhavi, Ferrer-Marin, Francisca, Ghevaert, Cedric, Feldman, Henry A., McFarland, Janice G., Chavda, Chaitanya, Sola-Visner, Martha
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2015
Subjects:
Platelets and Thrombopoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559934/
https://ncbi.nlm.nih.gov/pubmed/26209661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-11-611020
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