TLE3 is not a predictive biomarker for taxane sensitivity in the NCIC CTG MA.21 clinical trial

BACKGROUND: TLE3, a nuclear transcriptional repressor downstream of WNT signalling pathways, has been hypothesised as predictive of benefit from adjuvant taxane. METHODS: MA.21 tissue microarrays were constructed from 1097 out of 2104 (52%) patients. TLE3 staining by immunohistochemistry used valida...

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Enregistré dans:
Détails bibliographiques
Publié dans:Br J Cancer
Auteurs principaux: Bartlett, J M S, Nielsen, T O, Gao, D, Gelmon, K A, Quintayo, M A, Starczynski, J, Han, L, Burnell, M J, Levine, M N, Chen, B E, Shepherd, L E, Chapman, J W
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
Sujets:
Translational Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559832/
https://ncbi.nlm.nih.gov/pubmed/26284338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.271
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