A Physiologically Based Pharmacokinetic Drug–Disease Model to Predict Carvedilol Exposure in Adult and Paediatric Heart Failure Patients by Incorporating Pathophysiological Changes in Hepatic and Renal Blood Flows

BACKGROUND AND OBJECTIVE: Chronic diseases are associated with pathophysiological changes that could have profound impacts on drug pharmacokinetic behaviour, with a potential need to modify the administered drug therapy. It is important to acknowledge that most patients with chronic illnesses do not...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Clin Pharmacokinet
Main Authors: Rasool, Muhammad Fawad, Khalil, Feras, Läer, Stephanie
פורמט: Artigo
שפה:Inglês
יצא לאור: Springer International Publishing 2015
נושאים:
Original Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559583/
https://ncbi.nlm.nih.gov/pubmed/25773479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0253-7
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