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miRNAs and SAMHD1 regulation in vitro and in a model of HIV CNS disease

Pilakka-Kanthikeel et al. recently reported higher levels of the retroviral restriction factor sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) in astrocytes than in microglia, suggesting that SAMHD1 levels might explain in part the relatively refractory nature of...

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Publicat a:J Neuroinflammation
Autors principals: Witwer, Kenneth W., Buchanan, Erin L., Myers, Stephanie L., McAlexander, Melissa A.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559003/
https://ncbi.nlm.nih.gov/pubmed/26337901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0380-y
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