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Prazosin + naltrexone decreases alcohol drinking more effectively than does either drug alone in P rats with a protracted history of extensive voluntary alcohol drinking, dependence and multiple withdrawals

BACKGROUND: Prazosin (PRZ, an α(1)-adrenergic receptor antagonist) and naltrexone (NTX, a non-specific opioid receptor antagonist) each decrease alcohol drinking when administered to rats selectively-bred for high voluntary alcohol drinking (alcohol-preferring, or “P”), and the combination of PRZ+NT...

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Detalhes bibliográficos
Publicado no:Alcohol Clin Exp Res
Main Authors: Rasmussen, Dennis D, Kincaid, Carrie L, Froehlich, Janice C
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558320/
https://ncbi.nlm.nih.gov/pubmed/26260061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.12828
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