Genomic DISC1 disruption in hiPSCs alters Wnt signaling and neural cell fate

Genetic and clinical association studies have identified disrupted-in-schizophrenia 1 (DISC1) as a candidate risk gene for major mental illness. DISC1 is interrupted by a balanced chr(1;11) translocation in a Scottish family, in which the translocation predisposes to psychiatric disorders. We invest...

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Vydáno v:Cell Rep
Hlavní autoři: Srikanth, Priya, Han, Karam, Callahan, Dana G., Makovkina, Eugenia, Muratore, Christina R., Lalli, Matthew A., Zhou, Honglin, Boyd, Justin D., Kosik, Kenneth S., Selkoe, Dennis J., Young-Pearse, Tracy L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558300/
https://ncbi.nlm.nih.gov/pubmed/26299970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.061
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