Immune suppressive and pro-metastatic functions of myeloid-derived suppressive cells rely upon education from tumor-associated B cells

Myeloid-derived suppressive cells (MDSC) have been reported to promote metastasis, but the loss of cancer-induced B cells/B regulatory cells (tBregs) can block metastasis despite MDSC expansion in cancer. Here, using multiple murine tumor models and human MDSC, we show that MDSC populations which ex...

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Foilsithe in:Cancer Res
Main Authors: Bodogai, Monica, Moritoh, Kanako, Lee-Chang, Catalina, Hollander, Christine M., Sherman-Baust, Cheryl A., Wersto, Robert P., Araki, Yoshihiko, Miyoshi, Ichiro, Yang, Li, Trinchieri, Giorgio, Biragyn, Arya
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558269/
https://ncbi.nlm.nih.gov/pubmed/26183924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3077
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