Inhibition of calpain activation protects MPTP-induced nigral and spinal cord neurodegeneration, reduces inflammation, and improves gait dynamics in mice

Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, resulting in dopaminergic (DA) neuronal loss in the substantia nigra pars compacta (SNpc) and damage to extranigral spinal cord neurons. Current therapies do not prevent the disease progression. Hence, developing effica...

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Bibliographic Details
Published in:Mol Neurobiol
Main Authors: Samantaray, Supriti, Knaryan, Varduhi H., Shields, Donald C., Cox, April A., Haque, Azizul, Banik, Naren L.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558265/
https://ncbi.nlm.nih.gov/pubmed/26108182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-015-9255-6
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