Trametinib modulates cancer multidrug resistance by targeting ABCB1 transporter

Overexpression of adenine triphosphate (ATP)-binding cassette (ABC) transporters is one of the main reasons of multidrug resistance (MDR) in cancer cells. Trametinib, a novel specific small-molecule mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor, is currently used for the tr...

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Pubblicato in:Oncotarget
Autori principali: Qiu, Jian-Ge, Zhang, Yao-Jun, Li, Yong, Zhao, Jin-Ming, Zhang, Wen-Ji, Jiang, Qi-Wei, Mei, Xiao-Long, Xue, You-Qiu, Qin, Wu-Ming, Yang, Yang, Zheng, Di-Wei, Chen, Yao, Wei, Meng-Ning, Shi, Zhi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558166/
https://ncbi.nlm.nih.gov/pubmed/25915534
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