Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

Here, we show that new mitochondrial biogenesis is required for the anchorage independent survival and propagation of cancer stem-like cells (CSCs). More specifically, we used the drug XCT790 as an investigational tool, as it functions as a specific inhibitor of the ERRα-PGC1 signaling pathway, whic...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: De Luca, Arianna, Fiorillo, Marco, Peiris-Pagès, Maria, Ozsvari, Bela, Smith, Duncan L., Sanchez-Alvarez, Rosa, Martinez-Outschoorn, Ubaldo E., Cappello, Anna Rita, Pezzi, Vincenzo, Lisanti, Michael P., Sotgia, Federica
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558115/
https://ncbi.nlm.nih.gov/pubmed/26087310
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