High Prevalence of inhA Promoter Mutations among Patients with Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa

BACKGROUND: Drug-resistant tuberculosis (TB) remains extremely difficult to treat because there are often few remaining active medications and limited diagnostic options to detect resistance. Resistance to isoniazid is typically caused by mutations in either katG or the inhA promoter. inhA mutations...

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Udgivet i:PLoS One
Main Authors: Niehaus, Abraham J., Mlisana, Koleka, Gandhi, Neel R., Mathema, Barun, Brust, James C. M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557915/
https://ncbi.nlm.nih.gov/pubmed/26332235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135003
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