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Overcoming stroma-mediated treatment resistance in chronic lymphocytic leukemia through BCL-2 inhibition

Despite recent advances in the treatment of chronic lymphocytic leukemia (CLL) with chemoimmunotherapy, many CLL patients are older or frail and cannot tolerate aggressive chemotherapy. Even those who can inevitably develop resistance due to factors such as deletion of pro-apoptotic factors like TP5...

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Publicado en:Leuk Lymphoma
Main Authors: Davids, Matthew S., Letai, Anthony, Brown, Jennifer R.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557771/
https://ncbi.nlm.nih.gov/pubmed/23614795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2013.796051
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