Monozygotic twins discordant for common variable immunodeficiency reveal impaired DNA demethylation during naïve-to-memory B-cell transition

Common variable immunodeficiency (CVID), the most frequent primary immunodeficiency characterized by loss of B-cell function, depends partly on genetic defects, and epigenetic changes are thought to contribute to its aetiology. Here we perform a high-throughput DNA methylation analysis of this disor...

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Udgivet i:Nat Commun
Main Authors: Rodríguez-Cortez, Virginia C., del Pino-Molina, Lucia, Rodríguez-Ubreva, Javier, Ciudad, Laura, Gómez-Cabrero, David, Company, Carlos, Urquiza, José M., Tegnér, Jesper, Rodríguez-Gallego, Carlos, López-Granados, Eduardo, Ballestar, Esteban
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557293/
https://ncbi.nlm.nih.gov/pubmed/26081581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8335
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