Blocking the PI3K/AKT pathway enhances mammalian reovirus replication by repressing IFN-stimulated genes

Many host cellular signaling pathways were activated and exploited by virus infection for more efficient replication. The PI3K/Akt pathway has recently attracted considerable interest due to its role in regulating virus replication. This study demonstrated for the first time that the mammalian reovi...

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Udgivet i:Front Microbiol
Main Authors: Tian, Jin, Zhang, Xiaozhan, Wu, Hongxia, Liu, Chunguo, Li, Zhijie, Hu, Xiaoliang, Su, Shuo, Wang, Lin-Fa, Qu, Liandong
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557281/
https://ncbi.nlm.nih.gov/pubmed/26388843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2015.00886
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