Combination Immunotherapy after ASCT for Multiple Myeloma Using MAGE-A3/Poly-ICLC Immunizations Followed by Adoptive Transfer of Vaccine-Primed and Costimulated Autologous T Cells

PURPOSE: Myeloma-directed cellular immune responses after autologous stem cell transplantation (ASCT) may reduce relapse rates. We studied whether coinjecting the TLR-3 agonist and vaccine adjuvant Poly-ICLC with a MAGE-A3 peptide vaccine was safe and would elicit a high frequency of vaccine-directe...

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Publicado no:Clin Cancer Res
Main Authors: Rapoport, Aaron P., Aqui, Nicole A., Stadtmauer, Edward A, Vogl, Dan T., Xu, Yin Yan, Kalos, Michael, Cai, Ling, Fang, Hong-Bin, Weiss, Brendan M., Badros, Ashraf, Yanovich, Saul, Akpek, Gorgun, Tsao, Patricia, Cross, Alan, Mann, Dean, Philip, Sunita, Kerr, Naseem, Brennan, Andrea, Zheng, Zhaohui, Ruehle, Kathleen, Milliron, Todd, Strome, Scott E., Salazar, Andres M., Levine, Bruce L., June, Carl H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557204/
https://ncbi.nlm.nih.gov/pubmed/24520093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2817
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