A Splice Region Variant in LDLR Lowers Non-high Density Lipoprotein Cholesterol and Protects against Coronary Artery Disease

Through high coverage whole-genome sequencing and imputation of the identified variants into a large fraction of the Icelandic population, we found four independent signals in the low density lipoprotein receptor gene (LDLR) that associate with levels of non-high density lipoprotein cholesterol (non...

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Detaylı Bibliyografya
Yayımlandı:PLoS Genet
Asıl Yazarlar: Gretarsdottir, Solveig, Helgason, Hannes, Helgadottir, Anna, Sigurdsson, Asgeir, Thorleifsson, Gudmar, Magnusdottir, Audur, Oddsson, Asmundur, Steinthorsdottir, Valgerdur, Rafnar, Thorunn, de Graaf, Jacqueline, Daneshpour, Maryam S., Hedayati, Mehdi, Azizi, Fereidoun, Grarup, Niels, Jørgensen, Torben, Vestergaard, Henrik, Hansen, Torben, Eyjolfsson, Gudmundur, Sigurdardottir, Olof, Olafsson, Isleifur, Kiemeney, Lambertus A., Pedersen, Oluf, Sulem, Patrick, Thorgeirsson, Gudmundur, Gudbjartsson, Daniel F., Holm, Hilma, Thorsteinsdottir, Unnur, Stefansson, Kari
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556698/
https://ncbi.nlm.nih.gov/pubmed/26327206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005379
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