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The role of Dbf4/Drf1-dependent kinase Cdc7 (Ddk) in DNA damage checkpoint control

The Dbf4/Drf1-dependent S-phase promoting kinase Cdc7 (Ddk) is thought to be an essential target inactivated by the S-phase checkpoint machinery that inhibits DNA replication. However, we show here that the complex formation, chromatin-association, and kinase activity of Ddk are not inhibited during...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Tsuji, Toshiya, Lau, Eric, Chiang, Gary G., Jiang, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556649/
https://ncbi.nlm.nih.gov/pubmed/19111665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.12.005
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