Glucocorticoid Receptor Activation Inhibits Chemotherapy-induced Cell Death in High-grade Serous Ovarian Carcinoma

OBJECTIVES: To test the hypothesis that glucocorticoid receptor (GR) activation increases resistance to chemotherapy in high-grade serous ovarian cancer (HGS-OvCa) and that treatment with a GR antagonist will improve sensitivity to chemotherapy. METHODS: GR expression was assessed in OvCa cell lines...

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Gepubliceerd in:Gynecol Oncol
Hoofdauteurs: Stringer-Reasor, Erica M., Baker, Gabrielle M., Skor, Maxwell N., Kocherginsky, Masha, Lengyel, Ernst, Fleming, Gini F., Conzen, Suzanne D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556542/
https://ncbi.nlm.nih.gov/pubmed/26115975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2015.06.033
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