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Pleiotropic, heart rate-independent cardioprotection by ivabradine

BACKGROUND AND PURPOSE: In pigs, ivabradine reduces infarct size even when given only at reperfusion and in the absence of heart rate reduction. The mechanism of this non-heart rate-related cardioprotection is unknown. Hence, in the present study we assessed the pleiotropic action of ivabradine in m...

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Détails bibliographiques
Publié dans:Br J Pharmacol
Auteurs principaux: Kleinbongard, P, Gedik, N, Witting, P, Freedman, B, Klöcker, N, Heusch, G
Format: Artigo
Langue:Inglês
Publié: John Wiley & Sons, Ltd 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556475/
https://ncbi.nlm.nih.gov/pubmed/26076181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13220
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