PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis

BACKGROUND AND PURPOSE: cAMP plays an important role in the transduction of signalling pathways involved in neuroprotection and immune regulation. Control of the levels of this nucleotide by inhibition of cAMP-specific PDEs such as PDE7 may affect the pathological processes of neuroinflammatory dise...

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Sparad:
Bibliografiska uppgifter
I publikationen:Br J Pharmacol
Huvudupphovsmän: Mestre, L, Redondo, M, Carrillo-Salinas, F J, Morales-García, J A, Alonso-Gil, S, Pérez-Castillo, A, Gil, C, Martínez, A, Guaza, C
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley & Sons, Ltd 2015
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556467/
https://ncbi.nlm.nih.gov/pubmed/25994655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13192
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