Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells

Malignant mesothelioma (MM) shows inactivation of the BRCA1-associated protein 1 (BAP1) gene. In this study, we found BAP1 mutations in 5 (26%) of the 19 cell lines that we established from Japanese MM patients, and examined functional differences between the WT and mutant BAP1. First, we studied th...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Hakiri, Shuhei, Osada, Hirotaka, Ishiguro, Futoshi, Murakami, Hideki, Murakami-Tonami, Yuko, Yokoi, Kohei, Sekido, Yoshitaka
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556387/
https://ncbi.nlm.nih.gov/pubmed/26011428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12698
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