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HIV-1 Drug Resistance and Second-line Treatment in Children Randomized to Switch at Low versus Higher RNA Thresholds

BACKGROUND: The PENPACT-1 trial compared virologic thresholds to determine when to switch to second-line antiretroviral therapy (ART). Using PENPACT-1 data, we aimed to describe HIV-1 drug resistance accumulation on first-line ART by virologic threshold. METHODS: PENPACT-1 had a 2x2 factorial design...

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Detalhes bibliográficos
Publicado no:J Acquir Immune Defic Syndr
Main Authors: Harrison, Linda, Melvin, Ann, Fiscus, Susan, Saidi, Yacine, Nastouli, Eleni, Harper, Lynda, Compagnucci, Alexandra, Babiker, Abdel, McKinney, Ross, Gibb, Diana, Tudor-Williams, Gareth
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556171/
https://ncbi.nlm.nih.gov/pubmed/26322666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000000671
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