Whole-genome sequencing provides new insights into the clonal architecture of Barrett’s esophagus and esophageal adenocarcinoma

The molecular genetic relationship between esophageal adenocarcinoma (EAC) and its precursor lesion, Barrett’s esophagus, is poorly understood. Using whole-genome sequencing on 23 paired Barrett’s esophagus and EAC samples, together with one in-depth Barrett’s esophagus case-study sampled over time...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Ross-Innes, Caryn S., Becq, Jennifer, Warren, Andrew, Cheetham, R. Keira, Northen, Helen, O’Donovan, Maria, Malhotra, Shalini, di Pietro, Massimiliano, Ivakhno, Sergii, He, Miao, Weaver, Jamie M.J., Lynch, Andy G., Kingsbury, Zoya, Ross, Mark, Humphray, Sean, Bentley, David, Fitzgerald, Rebecca C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556068/
https://ncbi.nlm.nih.gov/pubmed/26192915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3357
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