ColE1-Plasmid Production in Escherichia coli: Mathematical Simulation and Experimental Validation

Plasmids have become very important as pharmaceutical gene vectors in the fields of gene therapy and genetic vaccination in the past years. In this study, we present a dynamic model to simulate the ColE1-like plasmid replication control, once for a DH5α-strain carrying a low copy plasmid (DH5α-pSUP...

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Bibliografiske detaljer
Udgivet i:Front Bioeng Biotechnol
Main Authors: Freudenau, Inga, Lutter, Petra, Baier, Ruth, Schleef, Martin, Bednarz, Hanna, Lara, Alvaro R., Niehaus, Karsten
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015
Fag:
Bioengineering and Biotechnology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4555960/
https://ncbi.nlm.nih.gov/pubmed/26389114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2015.00127
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