ColE1-Plasmid Production in Escherichia coli: Mathematical Simulation and Experimental Validation

Plasmids have become very important as pharmaceutical gene vectors in the fields of gene therapy and genetic vaccination in the past years. In this study, we present a dynamic model to simulate the ColE1-like plasmid replication control, once for a DH5α-strain carrying a low copy plasmid (DH5α-pSUP...

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Vydáno v:Front Bioeng Biotechnol
Hlavní autoři: Freudenau, Inga, Lutter, Petra, Baier, Ruth, Schleef, Martin, Bednarz, Hanna, Lara, Alvaro R., Niehaus, Karsten
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2015
Témata:
Bioengineering and Biotechnology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4555960/
https://ncbi.nlm.nih.gov/pubmed/26389114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2015.00127
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