The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold

B lymphocytes use B cell receptors (BCRs) to sense the physical features of the antigens. However, the sensitivity and threshold for the activation of BCRs resulting from the stimulation by mechanical forces are unknown. Here, we addressed this question using a double-stranded DNA-based tension gaug...

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Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Wan, Zhengpeng, Chen, Xiangjun, Chen, Haodong, Ji, Qinghua, Chen, Yingjia, Wang, Jing, Cao, Yiyun, Wang, Fei, Lou, Jizhong, Tang, Zhuo, Liu, Wanli
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2015
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4555871/
https://ncbi.nlm.nih.gov/pubmed/26258882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06925
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