Constitutive and ghrelin-dependent GHSR1a activation impairs Ca(V)2.1 and Ca(V)2.2 currents in hypothalamic neurons

The growth hormone secretagogue receptor type 1a (GHSR1a) has the highest known constitutive activity of any G protein–coupled receptor (GPCR). GHSR1a mediates the action of the hormone ghrelin, and its activation increases transcriptional and electrical activity in hypothalamic neurons. Although GH...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Gen Physiol
Autori principali: López Soto, Eduardo Javier, Agosti, Francina, Cabral, Agustina, Mustafa, Emilio Roman, Damonte, Valentina Martínez, Gandini, Maria Alejandra, Rodríguez, Silvia, Castrogiovanni, Daniel, Felix, Ricardo, Perelló, Mario, Raingo, Jesica
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2015
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4555474/
https://ncbi.nlm.nih.gov/pubmed/26283199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201511383
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi