Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities

Serine/arginine-rich splicing factor 2 (SRSF2) is an RNA-binding protein that plays important roles in splicing of mRNA precursors. SRSF2 mutations are frequently found in patients with myelodysplastic syndromes and certain leukemias, but how these mutations affect SRSF2 function has only begun to b...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zhang, Jian, Lieu, Yen K., Ali, Abdullah M., Penson, Alex, Reggio, Kathryn S., Rabadan, Raul, Raza, Azra, Mukherjee, Siddhartha, Manley, James L.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553800/
https://ncbi.nlm.nih.gov/pubmed/26261309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514105112
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