Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities

Serine/arginine-rich splicing factor 2 (SRSF2) is an RNA-binding protein that plays important roles in splicing of mRNA precursors. SRSF2 mutations are frequently found in patients with myelodysplastic syndromes and certain leukemias, but how these mutations affect SRSF2 function has only begun to b...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Zhang, Jian, Lieu, Yen K., Ali, Abdullah M., Penson, Alex, Reggio, Kathryn S., Rabadan, Raul, Raza, Azra, Mukherjee, Siddhartha, Manley, James L.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2015
Предметы:
PNAS Plus
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553800/
https://ncbi.nlm.nih.gov/pubmed/26261309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514105112
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