Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities

Serine/arginine-rich splicing factor 2 (SRSF2) is an RNA-binding protein that plays important roles in splicing of mRNA precursors. SRSF2 mutations are frequently found in patients with myelodysplastic syndromes and certain leukemias, but how these mutations affect SRSF2 function has only begun to b...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Zhang, Jian, Lieu, Yen K., Ali, Abdullah M., Penson, Alex, Reggio, Kathryn S., Rabadan, Raul, Raza, Azra, Mukherjee, Siddhartha, Manley, James L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553800/
https://ncbi.nlm.nih.gov/pubmed/26261309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514105112
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