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Key driving forces in the biosynthesis of autoinducing peptides required for staphylococcal virulence

Staphylococci produce autoinducing peptides (AIPs) as quorum-sensing signals that regulate virulence. These AIPs feature a thiolactone macrocycle that connects the peptide C terminus to the side chain of an internal cysteine. AIPs are processed from ribosomally synthesized precursors [accessory gene...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Wang, Boyuan, Zhao, Aishan, Novick, Richard P., Muir, Tom W.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553796/
https://ncbi.nlm.nih.gov/pubmed/26261307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506030112
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