Conformational Properties of Seven Toac-Labeled Angiotensin I Analogues Correlate with Their Muscle Contraction Activity and Their Ability to Act as ACE Substrates

Conformational properties of the angiotensin II precursor, angiotensin I (AngI) and analogues containing the paramagnetic amino acid TOAC (2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid) at positions 0, 1, 3, 5, 8, 9, and 10, were examined by EPR, CD, and fluorescence. The conformati...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Teixeira, Luis Gustavo D., Malavolta, Luciana, Bersanetti, Patrícia A., Schreier, Shirley, Carmona, Adriana K., Nakaie, Clovis R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552746/
https://ncbi.nlm.nih.gov/pubmed/26317625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136608
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