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Increased μ-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis

Childhood acute lymphoblastic leukemia (ALL) blasts are characterized by inhibited apoptosis promoting fast disease progress. It is known that in chronic lymphocytic and acute myeloid leukemias the reduced apoptosis is strongly related with the activity of calpain-calpastatin system (CCS) composed o...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mikosik, Anna, Henc, Izabella, Ruckemann-Dziurdzińska, Katarzyna, Frąckowiak, Joanna E., Płoszyńska, Anna, Balcerska, Anna, Bryl, Ewa, Witkowski, Jacek M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552652/
https://ncbi.nlm.nih.gov/pubmed/26317226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136615
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